Technology area

Drug delivery

752 funded awards, $481.1M total, FY2023-FY2025.

Data current as of 2026-05-11

Pattern read

Drug delivery is broadly distributed, with NIAID (165), NCI (118), and NIDDK (72) leading. Cancer drug delivery (nanoparticles, ADCs, tumor-targeting) and infectious-disease formulation work account for the bulk of activity. Median award is $495K, near the dataset median. The mechanism mix is balanced: 360 R44, 212 R43, and a strong STTR slice (R41 at 124). Concentration is low at 3.9%; many firms appear once or twice, no clear dominant vendors. The tag bundles oral, inhaled, injectable, transdermal, and implantable delivery modalities, so the underlying chemistry stories differ widely from one record to another.

Fit indicators

  • Broad IC distribution. The right IC depends on the therapeutic indication, not the delivery platform.
  • Strong STTR presence (R41 at 124). Delivery technologies often originate in academic chemistry/engineering labs.

Watchouts

  • 'Drug delivery platform' stories are often disadvantaged versus indication-specific submissions. Reviewers want a lead asset and indication, not a platform-only pitch.

Where the money sat, by Institute / Center

IC funding decisions are set by portfolio priorities, NOFO scope, and program-officer judgment. These are funded records, not predictions of future funding.

ICNameRecordsMedian award
AI (NIAID) National Institute of Allergy and Infectious Diseases 165 $320,863
CA (NCI) National Cancer Institute 118 $835,016
DK (NIDDK) National Institute of Diabetes and Digestive and Kidney Diseases 72 $775,236
GM (NIGMS) National Institute of General Medical Sciences 65 $349,952
HL (NHLBI) National Heart Lung and Blood Institute 61 $807,362
EY (NEI) National Eye Institute 45 $720,183
AG (NIA) National Institute on Aging 37 $500,000
NS (NINDS) National Institute of Neurological Disorders and Stroke 36 $497,229
DA (NIDA) National Institute on Drug Abuse 30 $356,771
TR (NCATS) National Center for Advancing Translational Sciences 19 $348,848
HD (NICHD) Eunice Kennedy Shriver National Institute of Child Health and Human Development 18 $872,932
DE (NIDCR) National Institute of Dental and Craniofacial Research 15 $413,298
AR (NIAMS) National Institute of Arthritis and Musculoskeletal and Skin Diseases 14 $295,358
ES (NIEHS) National Institute of Environmental Health Sciences 11 $306,789
DC (NIDCD) National Institute on Deafness and Other Communication Disorders 10 $339,450
MH (NIMH) National Institute of Mental Health 8 $352,388
AA (NIAAA) National Institute on Alcohol Abuse and Alcoholism 7 $626,743
AT (NCCIH) National Center for Complementary and Integrative Health 6 $495,765
EB (NIBIB) National Institute of Biomedical Imaging and Bioengineering 5 $374,095
MD (NIMHD) National Institute on Minority Health and Health Disparities 3 $1,482,405
HG (NHGRI) National Human Genome Research Institute 3 $347,026
OD NIH Office of the Director 3 $270,428
LM (NLM) National Library of Medicine 1 $349,432

FOA / NOFO routes

Opportunity number prefixes: PA = Parent Announcement (broad, omnibus, multiple ICs), PAR = Parent with Special Review, PAS = Parent with set-aside funds, RFA = Request for Applications (targeted, single-IC, fixed budget). Status unknown means the pipeline has not verified whether the FOA is currently posting awards; the SBIR omnibus has been in reauthorization gap during this window. See the glossary for full definitions.

OpportunityStatusRecords
PA-22-176 unknown 166
PA-23-230 unknown 120
PA-21-259 unknown 88
PA-24-245 unknown 57
PA-22-178 unknown 52
PA-23-232 unknown 42
PA-24-247 unknown 26
PA-21-262 unknown 25
PA-20-260 unknown 17
PA-20-272 unknown 12
RFA-DA-23-021 unknown 9
PA-22-177 unknown 9
PAR-22-073 unknown 8
PA-23-231 unknown 7
PA-21-260 unknown 7
PAS-19-316 unknown 7
PA-20-265 unknown 7
RFA-HL-23-008 unknown 6
PAS-22-197 unknown 6
PA-20-262 unknown 5
PA-21-345 unknown 5
PA-19-272 unknown 5
RFA-HL-23-009 unknown 4
PAS-22-196 unknown 3
RFA-NS-20-010 unknown 3
RFA-DA-22-023 unknown 3
RFA-MD-23-003 unknown 3
RFA-NS-23-007 unknown 3
PAR-21-225 unknown 3
PAS-19-317 unknown 3
PA-19-273 unknown 2
PA-23-233 unknown 2
RFA-CA-23-034 unknown 2
RFA-AG-24-042 unknown 2
PA-25-212 unknown 2
RFA-CA-23-035 unknown 2
PA-24-246 unknown 2
PA-18-574 unknown 2
PA-20-047 unknown 2
PA-21-261 unknown 2
RFA-NS-20-009 unknown 2
RFA-DA-23-017 unknown 2
RFA-CA-24-023 unknown 1
RFA-CA-24-022 unknown 1
PAR-24-131 expired 1
PA-24-248 unknown 1
RFA-DA-19-019 unknown 1
RFA-HG-21-008 unknown 1
RFA-NS-23-006 unknown 1
PAR-20-129 unknown 1
RFA-DA-24-018 unknown 1
PA-23-189 unknown 1
PA-17-302 unknown 1
PAR-19-333 unknown 1
RFA-MD-22-004 unknown 1
RFA-CA-21-036 unknown 1
RFA-NS-20-011 unknown 1
RFA-DK-21-012 unknown 1
PA-21-268 unknown 1

Comparable funded projects

ApplIDFYICTitleOrganizationAmount
10932102 2025 NS Next-generation nanomedicine for acute ischemic stroke NANOMUSE, LLC $351,461
10932485 2025 DE RegendoGEL for guided pulp and dentin regeneration REGENDODENT, INC. $398,785
10997404 2025 AI Recombinant Outer Membrane Vesicles as a Novel Adjuvant for a Malaria Vaccine VERSATOPE THERAPEUTICS, INC. $999,993
11000385 2025 HD A novel intravaginal ring technology featuring the sustained release of natural progesterone for the prevention of preterm birth in at-risk women DARE BIOSCIENCE, INC. $1,016,258
11001572 2025 MH A parallelized imaging platform for accurate and efficient long-term assessment of brain organoid development RAMONA OPTICS, INC. $475,002
11003734 2025 AI Chikungunya Recombinant Subunit Vaccine HAWAII BIOTECH, INC. $998,229
11004996 2025 HL Improved Sirolimus-Analog Adventitial Delivery to Enhance Outcomes in Below-the-Knee Peripheral Artery Disease MERCATOR MEDSYSTEMS, INC. $1,000,000
11006908 2025 DE Improving Caries Diagnosis with Targeted Nanoparticle-Enhanced AI-Assisted Intraoral Imaging GREENMARK BIOMEDICAL, INC. $294,632

Review panels that have appeared on these records

Panel names use NIH's Center for Scientific Review (CSR) format: a 2-4 letter study-section code plus a meeting-cycle number in parentheses (e.g. ISB (12) = Instrumentation and Systems Development, cycle 12). SBIR/STTR review groups are temporary, meeting-specific bodies. The names below describe panels that have appeared on the cited funded-project records, not where future applications get assigned. NIH assigns panels at the time of submission based on the application content.

Limitations

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